Title: The analgesic drug, tramadol, acts as an agonist of the transient receptor potential vanilloid-1
Authors: Marincsák, Rita ×
Tóth, Balázs István
Czifra, Gabriella
Szabó, Tamás
Kovács, László
Bíró, Tamás #
Issue Date: Jun-2008
Publisher: Williams & Wilkins
Series Title: Anesthesia and Analgesia vol:106 issue:6 pages:1890-6
Abstract: Tramadol is an effective analgesic substance widely used in medical practice. Its therapeutic action have been mainly attributed to the activation of mu-opioid receptors as well as to the inhibition of neurotransmitter reuptake mechanisms and various voltage- and ligand-gated ion channels of the nociceptive system. As transient receptor potential vanilloid-1 (TRPV1, "the capsaicin receptor") has been shown to function as a central integrator molecule of pain sensation, our aim in the current study was to define the involvement of TRPV1 in the complex mechanism of action of tramadol.
ISSN: 0003-2999
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Ion Channel Research
× corresponding author
# (joint) last author

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