Title: Activation of transient receptor potential vanilloid-3 inhibits human hair growth
Authors: Borbíró, István ×
Lisztes, Erika
Tóth, Balázs István
Czifra, Gabriella
Oláh, Attila
Szöllosi, Attila G
Szentandrássy, Norbert
Nánási, Péter P
Péter, Zoltán
Paus, Ralf
Kovács, László
Bíró, Tamás #
Issue Date: Aug-2011
Publisher: Elsevier Science Pub. Co.
Series Title: Journal of Investigative Dermatology vol:131 issue:8 pages:1605-14
Article number: 10.1038/jid.2011.122
Abstract: In the current study, we aimed at identifying the functional role of transient receptor potential vanilloid-3 (TRPV3) ion channel in the regulation of human hair growth. Using human organ-cultured hair follicles (HFs) and cultures of human outer root sheath (ORS) keratinocytes, we provide the first evidence that activation of TRPV3 inhibits human hair growth. TRPV3 immunoreactivity was confined to epithelial compartments of the human HF, mainly to the ORS. In organ culture, TRPV3 activation by plant-derived (e.g., eugenol, 10-1,000 μM) or synthetic (e.g., 2-aminoethoxydiphenyl borate, 1-300 μM) agonists resulted in a dose-dependent inhibition of hair shaft elongation, suppression of proliferation, and induction of apoptosis and premature HF regression (catagen). Human ORS keratinocytes also expressed functional TRPV3, whose stimulation induced membrane currents, elevated intracellular calcium concentration, inhibited proliferation, and induced apoptosis. Of great importance, these effects on ORS keratinocytes were all mediated by TRPV3, as small interfering RNA-mediated silencing of TRPV3 effectively abrogated the cellular actions of the above agonists. These findings collectively support the concept that TRPV3 signaling is a significant player in human hair growth control. Therefore, TRPV3 and the related intracellular signaling mechanism might function as a promising target for pharmacological manipulations of clinically relevant hair growth disorders.
ISSN: 0022-202X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Non-KU Leuven Association publications
× corresponding author
# (joint) last author

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