Early cardiac dysfunction is rescued by upregulation of SERCA2a pump activity in a rat model of metabolic syndrome
Miklós, Z × Kemecsei, P Bíró, T Marincsák, R Tóth, Balázs István Op den Buijs, J Benis, E Drozgyik, A Ivanics, T #
Acta Physiologica vol:205 issue:3 pages:381-393
Various components of metabolic syndrome associate with cardiac intracellular calcium (Cai 2+) mishandling, a precipitating factor in the development of heart failure. We aimed to provide a thorough description of early stage Cai 2+-cycling alterations in the fructose-fed rat, an experimental model of the disorder, where insulin resistance, hypertension and dyslipidaemia act cooperatively on the heart.