Title: Cognitive abilities of Alzheimer's disease transgenic mice are modulated by social context and circadian rhythm
Authors: Kyrik, Anna ×
Mochol, Gabriela
Filipkowski, Robert K.
Wawrzyniak, Marcin
Lioudyno, Victoria
Knapska, Ewelina
Gorkiewicz, Tomasz
Balcerzyk, Marcin
Leski, Szymon
Van Leuven, Freddy
Lipp, Hans-Peter
Wojcik, Daniel K.
Kaczmarek, Leszek #
Issue Date: Dec-2011
Publisher: Bentham Science Publishers
Series Title: Current Alzheimer Research vol:8 issue:8 pages:883-892
Abstract: In the present study, we used a new training paradigm in the intelliCage automatic behavioral assessment system to investigate cognitive functions of the transgenic mice harboring London mutation of the human amyloid precursor protein (APP.V717I). Three groups of animals: 5-, 12- and 18-24-month old were subjected to both Water Maze training and the IntelliCage-based appetitive conditioning. The spatial memory deficit was observed in all three groups of transgenic mice in both behavioral paradigms. However, the APP mice were capable to learn normally when co-housed with the wild-type (WT) littermates, in contrast to clearly impaired learning observed when the transgenic mice were housed alone. Furthermore, in the transgenic mice kept in the Intellicage alone, the cognitive deficit of the young animals was modulated by the circadian rhythm, namely was prominent only during the active phase of the day. The novel approach to study the transgenic mice cognitive abilities presented in this paper offers new insight into cognitive dysfunctions of the Alzheimer's disease mouse model.
ISSN: 1567-2050
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Experimental Genetics and Transgenesis (-)
Department of Human Genetics - miscellaneous
× corresponding author
# (joint) last author

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