Title: GSK-3 alpha/beta kinases and amyloid production in vivo
Authors: Jaworski, Tomasz ×
Dewachter, Ilse
Lechat, Benoit
Gees, Maarten
Kremer, Anneke
Demedts, David
Borghgraef, Peter
Devijver, Herman
Kügler, Seb
Patel, Satish
Woodgett, Jim R
Van Leuven, Freddy #
Issue Date: Dec-2011
Publisher: Nature Publishing Group
Series Title: Nature vol:480 issue:7376 pages:E4-5; discussion E6
Article number: 10.1038/nature10615
Abstract: Arising from C. J. Phiel, C. A. Wilson, V. M.-Y. Lee & P. S. Klein 423, 435-439 (2003)A major unresolved issue in Alzheimer's disease is identifying the mechanisms that regulate proteolytic processing of amyloid precursor protein (APP)-glycogen synthase kinase-3 (GSK-3) isozymes are thought to be important in this regulation. Phiel et al. proposed that GSK-3α, but not GSK-3β, controls production of amyloid. We analysed the proteolytic processing of mouse and human APP in mouse brain in vivo in five different genetic and viral models. Our data do not yield evidence for either GSK-3α-mediated or GSK-3β-mediated control of APP processing in brain in vivo.
ISSN: 0028-0836
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Experimental Genetics and Transgenesis (-)
Department of Human Genetics - miscellaneous
× corresponding author
# (joint) last author

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