Age-related impairment of ultrasonic vocalization in Tau.P301L mice: possible implication for progressive language disorders
Menuet, Clément × Cazals, Yves Gestreau, Christian Borghgraef, Peter Gielis, Lies Dutschmann, Mathias Van Leuven, Fred Hilaire, Gérard #
Public Library of Sciene
PLoS One vol:6 issue:10 pages:e25770
Tauopathies, including Alzheimer's Disease, are the most frequent neurodegenerative diseases in elderly people and cause various cognitive, behavioural and motor defects, but also progressive language disorders. For communication and social interactions, mice produce ultrasonic vocalization (USV) via expiratory airflow through the larynx. We examined USV of Tau.P301L mice, a mouse model for tauopathy expressing human mutant tau protein and developing cognitive, motor and upper airway defects.