Title: Botulinum toxin potentiates cancer radiotherapy and chemotherapy
Authors: Ansiaux, Réginald ×
Baudelet, Christine
Cron, Greg O
Segers, Jérôme
Dessy, Chantal
Martinive, Philippe
De Wever, Julie
Verrax, Julien
Wauthier, Valérie
Beghein, Nelson
Grégoire, Vincent
Buc Calderon, Pedro
Feron, Olivier
Gallez, Bernard #
Issue Date: Feb-2006
Publisher: Association for Cancer Research
Series Title: Clinical Cancer Research vol:12 issue:4 pages:1276-1283
Abstract: Structural and functional abnormalities in the tumor vascular network are considered factors of resistance of solid tumors to cytotoxic treatments. To increase the efficacy of anticancer treatments, efforts must be made to find new strategies for transiently opening the tumor vascular bed to alleviate tumor hypoxia (source of resistance to radiotherapy) and improve the delivery of chemotherapeutic agents. We hypothesized that Botulinum neurotoxin type A (BoNT-A) could interfere with neurotransmitter release at the perivascular sympathetic varicosities, leading to inhibition of the neurogenic contractions of tumor vessels and therefore improving tumor perfusion and oxygenation.
ISSN: 1078-0432
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Cell Death Research & Therapy
× corresponding author
# (joint) last author

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