Title: Synthesis and antitumor evaluation of 8-phenylaminopyrimido[4,5-c]isoquinolinequinones
Authors: Vásquez, David ×
Rodríguez, Jaime A
Theoduloz, Cristina
Verrax, Julien
Calderon, Pedro Buc
Valderrama, Jaime A #
Issue Date: Sep-2009
Publisher: Pergamon Press
Series Title: Bioorganic & Medicinal Chemistry Letters vol:19 issue:17 pages:5060-2
Abstract: A series of 8-phenylaminopyrimido[4,5-c]isoquinoline-7,10-quinone derivatives were prepared by regioselective amination reaction of pyrimido[4,5-c]isoquinoline-7,10-quinones with arylamines in the presence of a Lewis acid catalyst. Preliminary evaluation of the members of the series against cancer cell lines and assays of activation of their cytotoxic activity on K562 cells with ascorbic acid are reported.
ISSN: 0960-894X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Cell Death Research & Therapy
× corresponding author
# (joint) last author

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