Resiniferatoxin mediated ablation of TRPV1+ neurons removes TRPA1 as well
Pecze, László × Pelsoczi, Péter Kecskes, Miklos Winter, Zoltán Papp, András Kaszás, Krisztián Letoha, Tamás Vizler, Csaba Oláh, Zoltán #
Canadian Journal of Neurological Sciences
Canadian Journal of Neurological Sciences vol:36 issue:2 pages:234-41
Resiniferatoxin, the most potent agonist of inflammatory pain/vanilloid receptor/cation channel (TRPV1) can be used for neuron subtype specific ablation of pain generating cells at the level of the peripheral nervous system by Ca(2+)-excytotoxicity. Molecular neurosurgery is an emerging technology either to alleviate severe pain in cancer or treat/prevent different local neuropathies. Our aim was determining sensory modalities that may be lost after resiniferatoxin treatment.