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Title: In vivo antitumour effect of combretastatin A-4 phosphate added to fractionated irradiation
Authors: Ahmed, B ×
Landuyt, W
Griffioen, A W
Van Oosterom, Allan
Van den Bogaert, Walter
Lambin, P #
Issue Date: 2006
Series Title: Anticancer research vol:26 issue:1A pages:307-10
Abstract: BACKGROUND: The study aimed at evaluating the potential benefit from a combination of fractionated ionising radiation with the vascular-targeting compound combretastatin A-4 phosphate (CA-4-P). MATERIALS AND METHODS: Syngenic rat rhabdomyosarcoma (R1), growing subcutaneously, was treated at 2 different sizes: either small (2 +/- 0.5 cm3) or large (10.94 +/- 0.6 cm3). Localised fractionated irradiation of the tumours (5 x 3 Gy) in 5 days was followed 1 day later by an intraperitoneal CA-4-P treatment (25 mglkg). RESULTS: The combined treatment of only large tumours resulted in a small additional growth delay when compared with radiotherapy only. CONCLUSION: The present data indicate a size-dependent increase in tumour growth delay from combining fractionated irradiation with CA-4-P.
ISSN: 0250-7005
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Department of Oncology - miscellaneous
Laboratory of Experimental Radiotherapy
× corresponding author
# (joint) last author

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