Title: TGFB1 and IL8 gene polymorphisms and susceptibility to visceral leishmaniasis
Authors: Frade, Amanda Farage
Oliveira, Lea Campos de
Costa, Dorcas Lamounier
Costa, Carlos Henrique Nery
Aquino, Dorlene
Van Weyenbergh, Johan
Barral-Netto, Manoel
Barral, Aldina
Kalil, Jorge
Goldberg, Anna Carla # ×
Issue Date: Jul-2011
Publisher: Elsevier Science
Series Title: Infection, Genetics and Evolution vol:11 issue:5 pages:912-916
Abstract: Visceral leishmaniasis (VL) or Kala-azar is a serious protozoan infectious disease caused by an obligate intracellular parasite. Cytokines have a major role in determining progression and severity of clinical manifestations in VL. We investigated polymorphisms in the TGFB1and IL8 genes, which are cytokines known to have a role in onset and severity of the disease. Polymorphisms at TGFB1 -509 C/T and +869 T/C, and IL8 -251 A/T were analyzed by a PCR-RFLP technique, in 198 patients with VL, 98 individuals with asymptomatic infection positive for a delayed-type hypersensitivity test (DTH+) and in 101 individuals with no evidence of infection (DTH-). The presence of the T allele in position -509 of the TGFB1 gene conferred a two-fold risk to develop infection both when including those with clinical symptoms (DTH+ and VL, grouped) or when considering DTH+ only, respectively p = 0.007, OR = 1.9 [1.19-3.02] and p = 0.012, OR = 2.01 [1.17-3.79], when compared with DTH- individuals. In addition, occurrence of hemorrhage was associated with TGFB1 -509 T allele. We suggest that the -509 T allele of the TGFB1 gene, a cytokine with a biologically relevant role in the natural history of the disease, may contribute to overall susceptibility to infection by Leishmania and to severity of the clinical disease.
ISSN: 1567-1348
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Non-KU Leuven Association publications
× corresponding author
# (joint) last author

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