Nicotinic acetylcholine receptor expression and susceptibility to cholinergic immunomodulation in human monocytes of smoking individuals
van der Zanden, Esmerij P × Hilbers, Francisca W Verseijden, Caroline van den Wijngaard, Rene M Skynner, Mike Lee, Kevin Ulloa, Luis Boeckxstaens, Guy de Jonge, Wouter J #
S. Karger Medical and Scientific Publishers
Neuroimmunomodulation vol:19 issue:4 pages:255-65
Smoking is generally accepted as a factor that affects the disease course in inflammatory bowel disease patients. Whether these effects can be contributed to the immunomodulatory effects of nicotine via nicotinic acetylcholine receptor (nAChR) activation is unclear. As previous data suggest that the α7 nicotinic acetylcholine receptor (CHRNA7) and its duplicated variant CHRFAM7A may specifically participate in the inflammatory response of monocytes, we evaluated whether repeated nicotine exposure or smoking affects monocyte CHRNA7 and CHRFAM7A expression and cholinergic immunomodulation.