Title: Recurrent breakpoints in the 14q32.13/TCL1A region in mature B-cell neoplasms with villous lymphocytes
Authors: Urbankova, Helena
Baens, Thijs
Michaux, Lucienne
Tousseyn, Thomas
Rack, Katrina
Katrincsakova, Beata
Finalet Ferreiro, Julio
Van Loo, Peter
De Kelver, Wim
Dierickx, Daan
Demuynck, Hilde
Delannoy, André
Verschuere, Johan
Jarošová, Marie
Peeters, Chris
Vandenberghe, Peter
Wlodarska, Iwona # ×
Issue Date: Dec-2012
Publisher: Harwood Academic Publishers
Series Title: Leukemia & Lymphoma vol:53 issue:12 pages:2449-2455
Abstract: Abstract Genetic background of mature B cell neoplasms with villous lymphocytes is poorly understood. We identified a novel breakpoint region at 14q32.13 that was rearranged together with IGH/14q32.33 in 4 BRAF/V600E-negative leukemia/lymphoma cases with villous lymphocytes carrying either t(14;14)(q32.13;q32.33) (3 patients) or del(14)(q32.13q32.33) (1 patient). The 14q32.13 breakpoints were mapped by FISH in the region harboring the TCL1A/TCL1B/TCL6 genes, known to be affected by TCRA/D-mediated t(14;14)(q11;q32)/inv(14)(q11q32) occurring in T-cell leukemia/lymphoma. To identify the target of t(14;14)(q32.13;q32.33) and del(14)(q32.13q32.33), qRT-PCR analysis of 25 candidate genes located centromerically and telomerically to the 14q3213 breakpoint was performed. Any of the analyzed genes was commonly overexpressed in the presented cases. Of note, upregulated transcription of TCL1A was observed in 2 cases. In summary, we provide evidence that IGH-mediated chromosomal aberrations affecting the 14q32.13/TCL1A-TCL6 region are recurrent in mature B-cell neoplasms with villous lymphocytes. Despite extensive qRT-PCR studies, molecular consequences of these novel aberrations remain elusive.
ISSN: 1042-8194
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Department of Human Genetics - miscellaneous
Laboratory for Genetics of Malignant Disorders
Translational Cell & Tissue Research
Human Genome Laboratory
× corresponding author
# (joint) last author

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