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Title: Downstream and intermediate interactions of synovial sarcoma-associated fusion oncoproteins and their implication for targeted therapy
Authors: Przybyl, Joanna ×
Jurkowska, Monika
Rutkowski, Piotr
Debiec-Rychter, Maria
Siedlecki, Janusz A #
Issue Date: Mar-2012
Publisher: Carfax International Publishers
Series Title: Sarcoma vol:2012 issue:online
Article number: article 249219
Abstract: Synovial sarcoma (SS), an aggressive type of soft tissue tumor, occurs mostly in adolescents and young adults. The origin and molecular mechanism of the development of SS remain only partially known. Over 90% of SS cases are characterized by the t(X;18)(p11.2;q11.2) translocation, which results mainly in the formation of SS18-SSX1 or SS18-SSX2 fusion genes. In recent years, several reports describing direct and indirect interactions of SS18-SSX1/SSX2 oncoproteins have been published. These reports suggest that the fusion proteins particularly affect the cell growth, cell proliferation, TP53 pathway, and chromatin remodeling mechanisms, contributing to SS oncogenesis. Additional research efforts are required to fully explore the protein-protein interactions of SS18-SSX oncoproteins and the pathways that are regulated by these partnerships for the development of effective targeted therapy.
URI: 
ISSN: 1357-714X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Department of Human Genetics - miscellaneous
Laboratory for Genetics of Malignant Disorders
× corresponding author
# (joint) last author

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