Matrix-assisted laser desorption ionization of low molecular weight compounds by Fourier transform laser microprobe mass spectrometry with external source
Kollensperger, G × Poels, Katrien VanVaeck, L VanRoy, W Struyf, H Grasserbauer, M #
John Wiley & Sons
Rapid Communications in Mass Spectrometry vol:10 issue:5 pages:538-550
3rd European Workshop on ICR BREMEN, GERMANY, SEP 04-06, 1995
Fourier transform laser microprobe mass spectrometry is used to perform matrix-assisted laser desorption/ionization (MALDI) experiments on low molecular weight compounds in the range up to 2 kDa. The optimal molar ratio of analyte to matrix is determined. The use of fructose as co-matrix and the effect of laser irradiance on the mass spectra are studied. The typical power density in MALDI is compared to the laser only mode. Specific experiments concerning the cationization of the analyte are described. The observations are interpreted in terms of previous concepts about DI in laser mass spectrometry of solids.