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Title: Loss of heterozygosity at chromosomes 3p and 17p in primary non-small cell lung cancer
Authors: Chmara, Magdalena ×
Wozniak, Agnieszka
Ochman, Karolina
Kobierska, Grazyna
Dziadziuszko, Rafal
Sosinska-Mielcarek, Katarzyna
Jassem, Ewa
Skokowski, Jan
Jassem, Jacek
Limon, Janusz #
Issue Date: Nov-2004
Series Title: Anticancer research vol:24 issue:6 pages:4259-63
Abstract: BACKGROUND: Loss of heterozygosity (LOH) of selected regions at chromosomes 3p and 17p in non-small cell lung cancer (NSCLC) and the association of these abnormalities with major clinical parameters and prognosis were studied. MATERIALS AND METHODS: The study group included 92 consecutive primary NSCLC tumours and four microsatellite markers from chromosome 3p and three markers from 17p were analyzed. RESULTS: LOH of at least one locus was found in 83% of all analyzed tumours. Most frequently deletion (58%) was found at locus D3S1481 (3p14.2). Sequence deletions of D17S520 (17p12) and TP53 (17p13.1) occurred in 52% of tumours. LOH occurrence at 3p and 17p was more frequent in squamous cell carcinomas compared to adenocarcinomas (89% vs. 75%), but this difference was not significant. CONCLUSION: No significant association was found between LOH on any analyzed loci and tumour stage (TNM) and grade (G). There was no correlation between LOH and survival.
ISSN: 0250-7005
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Experimental Oncology
× corresponding author
# (joint) last author

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