Title: G-CSF stem cell mobilization in human donors induces polymorphonuclear and mononuclear myeloid-derived suppressor cells
Authors: Luyckx, Ariane ×
Schouppe, Elio
Rutgeerts, Omer
Lenaerts, Caroline
Fevery, Sabien
Devos, Timothy
Dierickx, Daan
Waer, Mark
Van Ginderachter, Jo A
Billiau, An #
Issue Date: Apr-2012
Publisher: Academic Press
Series Title: Clinical Immunology vol:143 issue:1 pages:83-87
Abstract: The role of myeloid-derived suppressor cells (MDSC) is emerging in transplantation. An expansion of myeloid progenitor cells with suppressive capacity has been reported to occur as a bystander phenomenon in the course of allogeneic hematopoietic stem cell transplantation (alto-HSCT) protocols, particularly, in mice during bone marrow chimerism induction and in human stem cell donors during G-CSF-mobilization protocols. Hypothesizing that such 'regulatory myeloid cells' play a role in regulating post-transplant T-cell alloreactivity, we performed a phenotypical and functional characterization of these cells in peripheral blood stem cell grafts of G-CSF-treated donors. We demonstrate that expanding myeloid cells in the peripheral blood of G-CSF-mobilized donors comprise the typical phenotype of the mononuclear and polymorphonuclear MDSC-subtypes that were recently described in cancer patients, and that both MDSC-subsets have the capacity to regulate alloreactive T-cell responses in-vitro. This study provides the basis for investigating the clinical relevance of MDSC and MDSC-subtypes in human allo-HSCT. (C) 2012 Elsevier Inc. All rights reserved.
ISSN: 1521-6616
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Cell and Gene Therapy Applications (-)
Laboratory of Experimental Transplantation
× corresponding author
# (joint) last author

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