Title: The need for improved neutropenia risk assessment in DLBCL patients receiving R-CHOP-21: Findings from clinical practice
Authors: Salar, Antonio ×
Haioun, Corinne
Rossi, Francesca G
Duehrsen, Ulrich
Pettengell, Ruth
Johnsen, Hans E
Jaeger, Ulrich
Verhoef, Gregor
Schwenkglenks, Matthias
Bacon, Pamela
Bendall, Kate
Lugtenburg, Pieternella J #
Issue Date: May-2012
Publisher: Pergamon Press
Series Title: Leukemia Research vol:36 issue:5 pages:548-553
Article number: 10.1016/j.leukres.2012.02.002
Abstract: Febrile neutropenia (FN) risk-assessment and granulocyte-colony stimulating factor (G-CSF) prophylaxis use in clinical practice was evaluated in patients with diffuse large B-cell lymphoma receiving R-CHOP-21. More G-CSF primary prophylaxis was used in patients assessed as high FN risk, but R-CHOP-21 was associated with substantial myelotoxicity in both high-and low-risk groups. In a multivariate analysis, older age, poor performance status, lower baseline hemoglobin, and lack of G-CSF prophylaxis were significantly associated with occurrence of FN in any cycle. Results highlight the need for improved FN risk-assessment and thorough guideline adherence to further reduce FN and better support chemotherapy delivery. (C) 2012 Elsevier Ltd. All rights reserved.
ISSN: 0145-2126
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Cell and Gene Therapy Applications (-)
× corresponding author
# (joint) last author

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