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Title: Preferential stimulation by glucose of its oxidation relative to glycolysis in purified insulin-producing cells
Authors: De Vos, Annemie
Schuit, Frans
Malaisse, W J # ×
Issue Date: May-1991
Publisher: Published for the International Union of Biochemistry by Academic Press
Series Title: Biochemistry International vol:24 issue:1 pages:117-21
Abstract: A rise in extracellular D-glucose concentration increases to a greater relative extent the conversion of both D-[5-3H]glucose to 3HOH and D-[6-14C]glucose to 14CO2 in rat purified insulin-producing cells than previously observed in pancreatic islets. In the pure B-cells, the ratio between D-[6-14C]glucose oxidation and D-[5-3H]glucose utilization increases, in a sigmoidal manner, as a function of the hexose concentration. The preferential stimulation by D-glucose of mitochondrial oxidative events is proposed to represent an unusual but essential feature of the metabolic and, hence, functional response of these fuel-sensor cells.
ISSN: 0158-5231
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Gene Expression Unit
× corresponding author
# (joint) last author

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