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Title: Peroxisome proliferator-activated receptor-beta signaling contributes to enhanced proliferation of hepatic stellate cells
Authors: Hellemans, Karine
Michalik, Liliane
Dittie, Andrea
Knorr, Andreas
Rombouts, Krista
De Jong, Jan
Heirman, Carlo
Quartier, Erik
Schuit, Frans
Wahli, Walter
Geerts, Albert # ×
Issue Date: Jan-2003
Publisher: W.B. Saunders
Series Title: Gastroenterology vol:124 issue:1 pages:184-201
Abstract: The peroxisome proliferator-activated nuclear receptors (PPAR-alpha, PPAR-beta, and PPAR-gamma), which modulate the expression of genes involved in energy homeostasis, cell cycle, and immune function, may play a role in hepatic stellate cell activation. Previous studies focused on the decreased expression of PPAR-gamma in hepatic stellate cell activation but did not investigate the expression and role of the PPAR-alpha and -beta isotypes. The aim of this study was to evaluate the expression of the different PPARs during hepatic stellate cell activation in vitro and in situ and to analyze possible factors that might contribute to their expression. In a second part of the study, the effect of a PPAR-beta agonist on acute liver injury was evaluated.
URI: 
ISSN: 0016-5085
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Gene Expression Unit
× corresponding author
# (joint) last author

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