Type VIII adenylyl cyclase in rat beta cells: coincidence signal detector/generator for glucose and GLP-1
Delmeire, D Flamez, D Hinke, S A Cali, J J Pipeleers, D Schuit, Frans # ×
Diabetologia vol:46 issue:10 pages:1383-1393
The secretory function of pancreatic beta cells is synergistically stimulated by two signalling pathways which mediate the effects of nutrients and hormones such as glucagon-like peptide 1 (GLP-1), glucose-dependent insulinotropic peptide (GIP) or glucagon. These hormones are known to activate adenylyl cyclase in beta cells. We examined the type of adenylyl cyclase that is associated with this synergistic interaction.