Title: Clusters of conserved beta cell marker genes for assessment of beta cell phenotype
Authors: Martens, Geert A
Jiang, Lei
Hellemans, Karine H
Stangé, Geert
Heimberg, Harry
Nielsen, Finn C
Sand, Olivier
Van Helden, Jacques
Van Lommel, Leentje
Schuit, Frans
Gorus, Frans K
Pipeleers, Daniel G # ×
Issue Date: Oct-2011
Publisher: Public Library of Sciene
Series Title: PLoS One vol:6 issue:9 pages:e24134
Abstract: The aim of this study was to establish a gene expression blueprint of pancreatic beta cells conserved from rodents to humans and to evaluate its applicability to assess shifts in the beta cell differentiated state. Genome-wide mRNA expression profiles of isolated beta cells were compared to those of a large panel of other tissue and cell types, and transcripts with beta cell-abundant and -selective expression were identified. Iteration of this analysis in mouse, rat and human tissues generated a panel of conserved beta cell biomarkers. This panel was then used to compare isolated versus laser capture microdissected beta cells, monitor adaptations of the beta cell phenotype to fasting, and retrieve possible conserved transcriptional regulators.
ISSN: 1932-6203
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Non-KU Leuven Association publications
× corresponding author
# (joint) last author

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