Mechanisms of control of the free Ca2+ concentration in the endoplasmic reticulum of mouse pancreatic β-cells: interplay with cell metabolism and [Ca2+]c and role of SERCA2b and SERCA3
Ravier, Magalie A Daro, Dorothée Roma, Leticia Prates Jonas, Jean-Christophe Cheng-Xue, Rui Schuit, Frans Gilon, Patrick # ×
American Diabetes Association
Diabetes vol:60 issue:10 pages:2533-45
Sarco-endoplasmic reticulum Ca(2+)-ATPase 2b (SERCA2b) and SERCA3 pump Ca(2+) in the endoplasmic reticulum (ER) of pancreatic β-cells. We studied their role in the control of the free ER Ca(2+) concentration ([Ca(2+)](ER)) and the role of SERCA3 in the control of insulin secretion and ER stress.