Title: Toll-like receptor 2-deficient mice are protected from insulin resistance and beta cell dysfunction induced by a high-fat diet
Authors: Ehses, J A ×
Meier, D T
Wueest, S
Rytka, J
Boller, S
Wielinga, P Y
Schraenen, Anica
Lemaire, Katleen
Debray, S
Van Lommel, Leentje
Pospisilik, J A
Tschopp, O
Schultze, S M
Malipiero, U
Esterbauer, H
Ellingsgaard, H
Rütti, S
Schuit, Frans
Lutz, T A
Böni-Schnetzler, M
Konrad, D
Donath, Marc Y #
Issue Date: Aug-2010
Publisher: Springer-Verlag Heidelberg
Series Title: Diabetologia vol:53 issue:8 pages:1795-806
Abstract: Inflammation contributes to both insulin resistance and pancreatic beta cell failure in human type 2 diabetes. Toll-like receptors (TLRs) are highly conserved pattern recognition receptors that coordinate the innate inflammatory response to numerous substances, including NEFAs. Here we investigated a potential contribution of TLR2 to the metabolic dysregulation induced by high-fat diet (HFD) feeding in mice.
ISSN: 0012-186X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Gene Expression Unit
× corresponding author
# (joint) last author

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