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Title: Relating the chondrocyte gene network to growth plate morphology: from genes to phenotype
Authors: Kerkhofs, Johan ×
Roberts, Scott J
Luyten, Frank P
Van Oosterwyck, Hans
Geris, Liesbet #
Issue Date: 30-Apr-2012
Publisher: Public Library of Sciene
Series Title: PLoS One vol:7 issue:4 pages:e34729
Article number: e34729
Abstract: During endochondral ossification, chondrocyte growth and differentiation is controlled by many local signalling pathways. Due to crosstalks and feedback mechanisms, these interwoven pathways display a network like structure. In this study, a large-scale literature based logical model of the growth plate network was developed. The network is able to capture the different states (resting, proliferating and hypertrophic) that chondrocytes go through as they progress within the growth plate. In a first corroboration step, the effect of mutations in various signalling pathways of the growth plate network was investigated.
URI: 
ISSN: 1932-6203
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Cell and Gene Therapy Applications (-)
× corresponding author
# (joint) last author

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