ITEM METADATA RECORD
Title: Recovery from retinal lesions: molecular plasticity mechanisms in visual cortex far beyond the deprived zone
Other Titles: Retinal lesions induce protein changes
Authors: Hu, Tjing
Van den Bergh, Gert
Thorrez, Lieven
Heylen, Kevin
Eysel, Ulf T.
Arckens, Lut # ×
Issue Date: Dec-2011
Publisher: Oxford University Press
Series Title: Cerebral Cortex vol:21 issue:12 pages:2883-2892
Abstract: In cats with central retinal lesions, deprivation of the lesion projection zone (LPZ) in primary visual cortex (area 17) induces remapping of the cortical topography. Recovery of visually driven cortical activity in the LPZ involves distinct changes in protein expression. Recent observations, about molecular activity changes throughout area 17, challenge the view that its remote nondeprived parts would not be involved in this recovery process. We here investigated the dynamics of the protein expression pattern of remote nondeprived area 17 triggered by central retinal lesions to explore to what extent far peripheral area 17 would contribute to the topographic map reorganization inside the visual cortex. Using functional proteomics, we identified 40 proteins specifically differentially expressed between far peripheral area 17 of control and experimental animals 14 days to 8 months postlesion. Our results demonstrate that far peripheral area 17 is implicated in the functional adaptation to the visual deprivation, involving a meshwork of interacting proteins, operating in diverse pathways. In particular, endocytosis/exocytosis processes appeared to be essential via their intimate correlation with long-term potentiation and neurite outgrowth mechanisms.
URI: 
ISSN: 1047-3211
Publication status: published
KU Leuven publication type: IT
Appears in Collections:ESAT - STADIUS, Stadius Centre for Dynamical Systems, Signal Processing and Data Analytics
Development and Regeneration, Campus Kulak Kortrijk
Laboratory for Biological Psychology
Research Group Neuroplasticity and Neuroproteomics (-)
Animal Physiology and Neurobiology Section - miscellaneous
× corresponding author
# (joint) last author

Files in This Item:
File Description Status SizeFormat
Hu et al._2011_Cerebral Cortex_vol21_p2883-2892.pdf Published 527KbAdobe PDFView/Open Request a copy

These files are only available to some KU Leuven Association staff members

 




All items in Lirias are protected by copyright, with all rights reserved.

© Web of science