Title: Synthetic genetic polymers capable of heredity and evolution
Authors: Pinheiro, Vitor B ×
Taylor, Alexander I
Cozens, Christopher
Abramov, Mikhail
Renders, Marleen
Zhang, Su
Chaput, John C
Wengel, Jesper
Peak-Chew, Sew-Yeu
McLaughlin, Stephen H
Herdewijn, Piet
Holliger, Philipp #
Issue Date: Apr-2012
Publisher: American Association for the Advancement of Science
Series Title: Science vol:336 issue:6079 pages:341-4
Abstract: Genetic information storage and processing rely on just two polymers, DNA and RNA, yet whether their role reflects evolutionary history or fundamental functional constraints is currently unknown. With the use of polymerase evolution and design, we show that genetic information can be stored in and recovered from six alternative genetic polymers based on simple nucleic acid architectures not found in nature [xeno-nucleic acids (XNAs)]. We also select XNA aptamers, which bind their targets with high affinity and specificity, demonstrating that beyond heredity, specific XNAs have the capacity for Darwinian evolution and folding into defined structures. Thus, heredity and evolution, two hallmarks of life, are not limited to DNA and RNA but are likely to be emergent properties of polymers capable of information storage.
ISSN: 0036-8075
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Medicinal Chemistry (Rega Institute)
Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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