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Title: Altered irinotecan metabolism in a patient receiving phenytoin
Authors: Mathijssen, Ron H J ×
Sparreboom, Alex
Dumez, Herlinde
Van Oosterom, Allan
de Bruijn, Ernst #
Issue Date: Feb-2002
Series Title: Anti-cancer drugs vol:13 issue:2 pages:139-40
Abstract: The systemic exposure to the anticancer agent irinotecan (CPT-11) and its active metabolite SN-38 were 79 and 92% reduced, respectively, relative to literature data, by concomitant phenytoin therapy. This finding suggests that increased doses of CPT-11 should be given to patients treated simultaneously with these drugs, to achieve adequate levels of SN-38.
ISSN: 0959-4973
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Department of Oncology - miscellaneous
Laboratory of Experimental Oncology
× corresponding author
# (joint) last author

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