Communications in Agricultural and Applied Biological Sciences vol:77 issue:1 pages:183-187
symposium on applied biological sciences edition:17 location:Leuven date:10 February 2012
Belgian draught horses are susceptible to chronic progressive lymphoedema (CPL), a disorder with genetic predisposition. Breeding decisions require early diagnosis. Healthy individuals have minor elastin (ELN) turnover, eliciting only basic antibody formation (anti-ELN antibodies/AEAb’s). In CPL-affected draught horses, AEAb levels have been shown to correlate with clinical severity. It was hypothesized that AEAb levels in young horses, with no/minor clinical signs, indicate CPL susceptibility. Therefore, plasma samples, distal limb radiographs and clinical scores were obtained from stallions (< 36 months), and these data were linked to disease progression at least 2 years later. If initial AEAb levels correlate with the later disease status, this test could allow for early identification.