Title: Treatment of operable breast cancer in the elderly: a randomised clinical trial EORTC 10851 comparing tamoxifen alone with modified radical mastectomy
Authors: Fentiman, I S ×
Christiaens, Marie-Rose
Paridaens, Robert
Van Geel, A
Rutgers, E
Berner, J
de Keizer, G
Wildiers, J
Nagadowska, M
Legrand, C
Therasse, P #
Issue Date: Feb-2003
Series Title: European journal of cancer (Oxford, England : 1990) vol:39 issue:3 pages:309-316
Abstract: For treatment of early breast cancer in older women, little evidence is available from randomised trials. We conducted a randomised trial comparing modified radical mastectomy (MRM) with tamoxifen (TAM) as the sole initial therapy in 164 patients aged >/=70 years with operable breast cancer. 82 were treated by MRM and 82 with TAM. Survival curves were estimated using the Kaplan-Meier method: multivariate analyses were performed using the Cox's proportional hazards model. Endpoints included survival, time to first relapse or progression, loco-regional progression, time to distant progression and progression-free survival. After a median follow-up of approximately 10 years, there was a significantly decreased time to progression in the TAM only group (logrank P<0.0001) and significantly shorter time to local progression within the TAM group (logrank P<0.0001). Overall survival of the two groups was similar. The results indicate that tamoxifen alone leads to an unacceptably high rate of local progression or relapse.
ISSN: 0959-8049
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Multidisciplinary Breast Clinic Section (-)
Laboratory of Experimental Oncology
Surgical Oncology
× corresponding author
# (joint) last author

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