ITEM METADATA RECORD
Title: 11q13 is a Susceptibility Locus for Hormone Receptor Positive Breast Cancer
Authors: Lambrechts, Diether ×
Truong, Therese
Justenhoven, Christina
Humphreys, Manjeet K
Wang, Jean
Hopper, John L
Dite, Gillian S
Apicella, Carmel
Southey, Melissa C
Schmidt, Marjanka K
Broeks, Annegien
Hillemanns, Peter
Bogdanova, Natalia V
Antonenkova, Natalia N
Rogov, Yuri I
Karstens, Johann H
Khusnutdinova, Elza
Bermisheva, Marina
Prokofieva, Darya
Gancev, Shamil
Jakubowska, Anna
Cornelissen, Sten
Lubinski, Jan
Jaworska, Katarzyna
Durda, Katarzyna
Nordestgaard, Børge G
Bojesen, Stig E
Lanng, Charlotte
Mannermaa, Arto
Kataja, Vesa
Kosma, Veli-Matti
Hartikainen, Jaana M
Hien, Richard van
Radice, Paolo
Peterlongo, Paolo
Manoukian, Siranoush
Bernard, Loris
Couch, Fergus J
Olson, Janet E
Wang, Xianshu
Fredericksen, Zachary
Alnßs, Grethe Grenaker
Kristensen, Vessela
Sawyer, Elinor
Børresen-Dale, Anne-Lise
Devilee, Peter
Tollenaar, Robert A E M
Seynaeve, Caroline M
Hooning, Maartje J
García-Closas, Montserrat
Chanock, Stephen J
Lissowska, Jolanta
Sherman, Mark E
Hall, Per
Tomlinson, Ian
Liu, Jianjun
Czene, Kamila
Kang, Daehee
Yoo, Keun-Young
Noh, Dong-Young
Lindblom, Annika
Margolin, Sara
Dunning, Alison M
Pharoah, Paul D P
Easton, Douglas F
Kerin, Michael
Guénel, Pascal
Brauch, Hiltrud
Miller, Nicola
Milne, Roger L
Zamora, M Pilar
Pérez, José Ignacio Arias
Benítez, Javier
Hamann, Ute
Brüning, Thomas
The GENICA Network
Chang-Claude, Jenny
Eilber, Ursel
Hein, Rebecca
Nickels, Stefan
Flesch-Janys, Dieter
Wang-Gohrke, Shan
John, Esther M
Miron, Alexander
Winqvist, Robert
Pylkäs, Katri
Jukkola-Vuorinen, Arja
Grip, Mervi
Chenevix-Trench, Georgia
Beesley, Jonathan
Chen, Xiaoqing
kConFab Investigators
Australian Ovarian Cancer Study Group
Menegaux, Florence
Cordina-Duverger, Emilie
Shen, Chen-Yang
Yu, Jyh-Cherng
Wu, Pei-Ei
Hou, Ming-Feng
Andrulis, Irene L
Selander, Teresa
Glendon, Gord
Mulligan, Anna Marie
Anton-Culver, Hoda
Ziogas, Argyrios
Muir, Kenneth R
Lophatananon, Artitaya
Rattanamongkongul, Suthee
Puttawibul, Puttisak
Jones, Michael
Orr, Nicholas
Ashworth, Alan
Swerdlow, Anthony
Severi, Gianluca
Baglietto, Laura
Giles, Graham
Southey, Melissa
Marmé, Federik
Schneeweiss, Andreas
Sohn, Christof
Burwinkel, Barbara
Yesilyurt, Betul T
Neven, Patrick
Paridaens, Robert
Wildiers, Hans
Brenner, Hermann
Müller, Heiko
Arndt, Volker
Stegmaier, Christa
Meindl, Alfons
Schott, Sarah
Bartram, Claus R
Schmutzler, Rita K
Cox, Angela
Brock, Ian W
Elliott, Graeme
Cross, Simon S
Fasching, Peter A
Schulz-Wendtland, Ruediger
Ekici, Arif B
Beckmann, Matthias W
Fletcher, Olivia
Johnson, Nichola
Dos Santos Silva, Isabel
Peto, Julian
Nevanlinna, Heli
Muranen, Taru A
Aittomäki, Kristiina
Blomqvist, Carl
Dörk, Thilo
Schürmann, Peter
Bremer, Michael #
Issue Date: Jul-2012
Publisher: John Wiley & Sons, Inc.
Series Title: Human Mutation vol:33 issue:7 pages:1123-1132
Abstract: A recent two-stage genome-wide association study (GWAS) identified five novel breast cancer susceptibility loci on chromosomes 9, 10 and 11. To provide more reliable estimates of the relative risk associated with these loci and investigate possible heterogeneity by subtype of breast cancer, we genotyped the variants rs2380205, rs1011970, rs704010, rs614367, rs10995190 in 39 studies from the Breast Cancer Association Consortium (BCAC), involving 49,608 cases and 48,772 controls of predominantly European ancestry. Four of the variants showed clear evidence of association (P = 3 × 10-9) and weak evidence was observed for rs2380205 (P = 0.06). The strongest evidence was obtained for rs614367, located on 11q13 (per-allele odds ratio 1.21, P = 4 × 10-39). The association for rs614367 was specific to estrogen receptor (ER)-positive disease and strongest for ER plus progesterone receptor (PR)-positive breast cancer, whereas the associations for the other three loci did not differ by tumor subtype.
URI: 
ISSN: 1059-7794
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Translational Genetics (Vesalius Research Center) (+)
Laboratory of Experimental Oncology
Gynaecological Oncology
× corresponding author
# (joint) last author

Files in This Item:

There are no files associated with this item.

Request a copy

 




All items in Lirias are protected by copyright, with all rights reserved.

© Web of science