Title: Isolated lung perfusion with melphalan for resectable lung metastases: a phase I clinical trial
Authors: Hendriks, Jeroen M H ×
Grootenboers, Marco J J H
Schramel, Franz M N H
van Boven, Wim J
Stockman, Bernard
Seldenrijk, Cornelis A
ten Broecke, Pieter
Knibbe, Catherijne A J
Slee, Peter
de Bruijn, Ernst
Vlaeminck, Renate
Heeren, Jos
Vermorken, Jan B
van Putte, Bart
Romijn, Sander
Van Marck, Eric
Van Schil, Paul E Y #
Issue Date: Dec-2004
Publisher: Elsevier Science
Series Title: Annals of Thoracic Surgery vol:78 issue:6 pages:1919-26; discussion 1926-7
Abstract: BACKGROUND: Current 5-year survival after complete resection of pulmonary metastases is 20% to 40%, and many patients develop intrathoracic recurrences. Isolated lung perfusion is an experimental technique to deliver high-dose chemotherapy to the lung without systemic exposure. A phase I trial of isolated lung perfusion with melphalan (MN) combined with pulmonary metastasectomy for resectable lung metastases was conducted to define the dose-limiting toxicity and maximum tolerated dose. METHODS: From May 2001 to August 2003, 16 patients underwent isolated lung perfusion with MN, followed by surgical resection of lung metastases. Patients were treated with increasing MN doses (15, 30, 45, and 60 mg). For each dose level, normothermia (37 degrees C) and hyperthermia (42 degrees C) were evaluated (n = 3 per level). Serum samples were obtained during the procedure. Pulmonary, hematologic, and nonhematologic toxicities were recorded. The primary tumor was colorectal in 7 patients, renal in 5, sarcoma in 3, and salivary gland in 1. Isolated lung perfusion was performed unilaterally in 11 patients, and staged bilaterally in 5. RESULTS: In total, 21 procedures of isolated lung perfusion with complete metastasectomy were performed without technical difficulties. Operative mortality was 0%, and no systemic toxicity was encountered. Grade 3 pulmonary toxicity developed at a dose of 60 mg of MN at 37 degrees C in 2 of 3 patients at this dose, terminating the trial. CONCLUSIONS: Isolated lung perfusion with MN combined with pulmonary metastasectomy is feasible. Dose-limiting toxicity occurred at a dose of 60 mg of MN at 37 degrees C, and the maximum tolerated dose was set at 45 mg of MN at 42 degrees C.
ISSN: 0003-4975
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Department of Oncology - miscellaneous
× corresponding author
# (joint) last author

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