Title: Pathogenesis and classification of eosinophil disorders: a review of recent developments in the field
Authors: Valent, Peter ×
Gleich, Gerald J
Reiter, Andreas
Roufosse, Florence
Weller, Peter F
Hellmann, Andrzej
Metzgeroth, Georgia
Leiferman, Kristin M
Arock, Michel
Sotlar, Karl
Butterfield, Joseph H
Cerny-Reiterer, Sabine
Mayerhofer, Matthias
Vandenberghe, Peter
Haferlach, Torsten
Bochner, Bruce S
Gotlib, Jason
Horny, Hans-Peter
Simon, Hans-Uwe
Klion, Amy D #
Issue Date: Apr-2012
Series Title: Expert Review of Hematology vol:5 issue:2 pages:157-176
Abstract: Eosinophils and their products play an essential role in the pathogenesis of various reactive and neoplastic disorders. Depending on the underlying disease, molecular defect and involved cytokines, hypereosinophilia may develop and may lead to organ damage. In other patients, persistent eosinophilia is accompanied by typical clinical findings, but the causative role and impact of eosinophilia remain uncertain. For patients with eosinophil-mediated organ pathology, early therapeutic intervention with agents reducing eosinophil counts can be effective in limiting or preventing irreversible organ damage. Therefore, it is important to approach eosinophil disorders and related syndromes early by using established criteria, to perform all appropriate staging investigations, and to search for molecular targets of therapy. In this article, we review current concepts in the pathogenesis and evolution of eosinophilia and eosinophil-related organ damage in neoplastic and non-neoplastic conditions. In addition, we discuss classifications of eosinophil disorders and related syndromes as well as diagnostic algorithms and standard treatment for various eosinophil-related disorders.
ISSN: 1747-4086
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Department of Human Genetics - miscellaneous
× corresponding author
# (joint) last author

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