Title: Efficient synthesis and anti-enteroviral activity of 9-arylpurines
Authors: Aguado, Leire ×
Canela, María-Dolores
Thibaut, Hendrik Jan
Priego, Eva-María
Camarasa, María-José
Leyssen, Pieter
Neyts, Johan
Pérez-Pérez, María-Jesús #
Issue Date: Mar-2012
Series Title: European Journal of Medicinal Chemistry vol:49 pages:279-88
Abstract: To further explore the anti-enteroviral activity of 9-aryl-6-chloropurines, three different series of compounds with a dialkylamino, (alkyl)amido, or oxazolidinone substituent at the aryl ring have been synthesized, in most cases with the aid of microwave-assisted synthesis. The resulting compounds efficiently inhibit Coxsackie virus type B3 (CVB3) replication with EC(50) values varying from 3 to 15 μM, and with no significant toxicity in Vero cells. The most potent compounds also selectively inhibit the replication of other enteroviruses including Coxsackie virus B4 and Echo virus 11. The cross-resistance studies performed with different 9-aryl-6-chloropurines indicate that they all belong to the same pharmacological family and differ from other CVB3 drugs such as enviroxime.
ISSN: 0223-5234
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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