Title: Novel substituted 9-norbornylpurines and their activities against RNA viruses
Authors: Sála, Michal ×
Hřebabecký, Hubert
Leyssen, Pieter
Dejmek, Milan
Dračínský, Martin
De Palma, Armando
Neyts, Johan
Nencka, Radim #
Issue Date: Mar-2012
Publisher: Pergamon Press
Series Title: Bioorganic & Medicinal Chemistry Letters vol:22 issue:5 pages:1963-1968
Abstract: We report on the synthesis and the study of the structure-activity relationship of novel 9-norbornyl-6-chloropurine derivatives, which exert selective antiviral activity on the replication of Coxsackievirus B3. In particular, the synthetic approaches towards norbornyl derivatives bearing diverse side chains were studied. The main goal of the study was to determine the influence of the norbornane moiety substitution at positions 5' and 6' on selective antiviral activity with special regard to the liphophilicity profile of the substituent.
ISSN: 0960-894X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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