Title: A phase I first-in-human pharmacokinetic and pharmacodynamic study of serdemetan in patients with advanced solid tumors
Authors: Tabernero, Josep ×
Dirix, Luc
Schöffski, Patrick
Cervantes, Andrés
Lopez-Martin, Jose Antonio
Capdevila, Jaume
van Beijsterveldt, Ludy
Platero, Suso
Hall, Brett
Yuan, Zhilong
Knoblauch, Roland
Zhuang, Sen Hong #
Issue Date: Oct-2011
Publisher: Association for Cancer Research
Series Title: Clinical Cancer Research vol:17 issue:19 pages:6313-6321
Abstract: Originally isolated on the basis of its ability to induce p53, serdemetan showed potent activity in various preclinical models, inducing S-phase arrest and apoptosis in TP53 wild-type and mutant tumors. This study evaluated the safety and tolerability of serdemetan, determined the pharmacokinetic and pharmacodynamic profiles, and identified a recommended phase II dose.
ISSN: 1078-0432
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Experimental Oncology
× corresponding author
# (joint) last author

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