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Title: Synthesis, antiviral and cytotoxic activities of 2-(2-phenyl carboxylic acid)-3-phenylquinazolin -4(3H)-one derivatives
Authors: Selvam, P ×
Murugesh, N
Chandramohan, M
Pannecouque, Christophe
De Clercq, Erik #
Issue Date: Nov-2010
Publisher: Indian Pharmaceutical Association
Series Title: Indian Journal of Pharmaceutical Sciences vol:72 issue:6 pages:806-U147
Abstract: A series of novel 2,3-disubstitutedquinazolin-4(3H)-ones have been synthesized by condensation of 2-substituted benzo[1,3]oxazine-4-ones and anthranilic acid. Synthesized compounds were evaluated for in vitro antiviral activity against HIV, HSV and vaccinia viruses. 5-Bromo-2-(6-bromo-4-oxo-2-phenyl-4H-quinazolin-3-yl)-benzoic acid (MBR2) exhibited distinct antiviral activity against Herpes simplex and vaccinia viruses.
URI: 
ISSN: 0250-474X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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