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Title: Synthesis and anti-HIV activity of novel 2,4-disubstituted-7-methyl-1,1,3-trioxo-2H,4H-pyrazolo[4,5-e][1,2,4]thiadiazine derivatives
Authors: Zhan, P ×
Yan, R Z
Liu, X Y
Pannecouque, Christophe
Witvrouw, Myriam
De Clercq, Erik
Molina, M T
Vega, S #
Issue Date: Dec-2011
Series Title: Drug discoveries & therapeutics vol:5 issue:6 pages:279-85
Abstract: A series of novel 2,4-disubstituted-7-methyl-1,1,3-trioxo-2H,4H-pyrazolo[4,5-e][1,2,4]thiadiazines (PTDs) was prepared starting from a ring of pyrazolo[4,5-e][1,2,4]thiadiazine nuclei with two different alkyl halides obtained by a facile one-pot reaction. The structures of all synthesized compounds were confirmed by <sup>1</sup>H- and <sup>13</sup>C-NMR, infrared spectra (IR), and mass spectra (MS) spectroscopic analysis. Anti-HIV activity was evaluated and none of the compounds were found to inhibit HIV replication in human T-lymphocyte (MT-4) cell culture.
ISSN: 1881-7831
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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