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Title: Evaluation of semi-quantitative dynamic contrast-enhanced MRI parameters for prostate cancer in correlation to whole-mount histopathology
Authors: Isebaert, Sofie ×
De Keyzer, Frederik
Haustermans, Karin
Lerut, Evelyne
Roskams, Tania
Roebben, Ilse
Van Poppel, Hendrik
Joniau, Steven
Oyen, Raymond #
Issue Date: Mar-2012
Publisher: G. Thieme
Series Title: European Journal of Radiology vol:81 issue:3 pages:E217-E222
Abstract: PURPOSE: To evaluate the use of semi-quantitative dynamic contrast-enhanced MRI (DCE-MRI) parameters for the detection of prostatic carcinoma in correlation to whole-mount histopathology. MATERIALS AND METHODS: Fifty-three patients with biopsy-proven prostate cancer were examined by DCE-MRI at 1.5-T. Cancerous and benign prostatic tissue regions of interest were delineated based on the histopathology of whole-mount sections and several semi-quantitative parameters were calculated: time to peak (TTP), maximal contrast enhancement (Cpeak), speed of contrast uptake (Wash-in) and clearance rate of the contrast agent (Wash-out). The area under the ROC curve was determined for each parameter. RESULTS: Within individual patients, a consistently higher Cpeak and faster Wash-in were present in cancerous compared to benign prostatic tissue. Both the TTP and the Wash-out occurred more rapidly in tumour tissue than in normal prostatic tissue. Despite a considerable inter-patient overlap of parameter values between tumour and normal prostatic tissue, area under the ROC curve analysis demonstrated that the Wash-in was a good discriminator for cancer and benign tissue (AUC 0.82). Combination of the Wash-in and the Wash-out proved to be even more accurate (AUC 0.87) to discriminate between cancerous and benign prostatic regions. CONCLUSION: The Wash-in is a useful parameter for prostate cancer detection by DCE-MRI.
URI: 
ISSN: 0720-048X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Translational Cell & Tissue Research
Radiology
Urology Section (-)
Laboratory of Experimental Radiotherapy
× corresponding author
# (joint) last author

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