Title: Receptor cloning and heterologous expression--towards a new tool for drug discovery
Authors: Luyten, Walter ×
Leysen, J E #
Issue Date: Jun-1993
Publisher: Elsevier Ltd., Trends Journals
Series Title: Trends in Biotechnology vol:11 issue:6 pages:247-54
Abstract: The explosion in the number of cloned receptors presents the pharmaceutical industry with challenges to discover new drugs targeting those receptors; to find more-selective drugs for all novel receptor subtypes; and to learn more about the function of the receptors in order to discern the conditions where such drugs may be applied usefully as therapeutics. At the same time, receptor cloning affords an unprecedented opportunity to address these challenges: heterologously expressed recombinant human receptors can be used for drug screening and - through an improved understanding of structure-function relationship - possibly for drug design, while the receptor clones permit mobilization of the full power of molecular biology to elucidate the function of the receptors in health and disease.
ISSN: 0167-7799
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Non-KU Leuven Association publications
× corresponding author
# (joint) last author

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