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Title: A human homologue of the checkpoint kinase Cds1 directly inhibits Cdc25 phosphatase
Authors: Blasina, A ×
de Weyer, I V
Laus, M C
Luyten, Walter
Parker, A E
McGowan, C H #
Issue Date: Jan-1999
Publisher: Current Biology Ltd.
Series Title: Current Biology vol:9 issue:1 pages:1-10
Abstract: In human cells, the mitosis-inducing kinase Cdc2 is inhibited by phosphorylation on Thr14 and Tyr15. Disruption of these phosphorylation sites abrogates checkpoint-mediated regulation of Cdc2 and renders cells highly sensitive to agents that damage DNA. Phosphorylation of these sites is controlled by the opposing activities of the Wee1/Myt1 kinases and the Cdc25 phosphatase. The regulation of these enzymes is therefore likely to be crucial for the operation of the G2-M DNA-damage checkpoint.
ISSN: 0960-9822
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Non-KU Leuven Association publications
× corresponding author
# (joint) last author

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