Cloning and characterization of human histone deacetylase 8
Van den Wyngaert, I × de Vries, W Kremer, A Neefs, J Verhasselt, P Luyten, Walter Kass, S U #
Elsevier on behalf of the Federation of European Biochemical Societies
FEBS Letters vol:478 issue:1-2 pages:77-83
To date, seven different human histone deacetylases (HDACs) have been identified, which fall into two distinct classes. We have isolated and characterized a cDNA encoding a novel human HDAC, which we name HDAC8. HDAC8 shows a high degree of sequence similarity to HDAC1 and HDAC2 and thus belongs to the class I of HDACs. HDAC8 is expressed in a variety of tissues. Human cells overexpressing HDAC8 localize the protein in sub-nuclear compartments whereas HDAC1 shows an even nuclear distribution. In addition, the HDAC8 gene is localized on the X chromosome at position q13, which is close to the XIST gene and chromosomal breakpoints associated with preleukemia.