Title: The biogenesis of active Protein Phosphatase 2A holoenzymes: a tightly regulated process creating phosphatase specificity
Authors: Sents, Ward
Ivanova, Eli
Lambrecht, Caroline
Haesen, Dorien
Janssens, Veerle # ×
Issue Date: Jan-2013
Publisher: Published by Blackwell Pub. on behalf of the Federation of European Biochemical Societies
Series Title: FEBS Journal vol:280 pages:644-661
Abstract: Protein Phosphatase type 2A (PP2A) enzymes comprise a large family of Ser/Thr phosphatases with multiple functions in cellular signaling and physiology. The composition of heterotrimeric PP2A holoenzymes, resulting from the combinatorial assembly of a catalytic C, structural A and regulatory B-type subunit, provides the essential determinants for substrate specificity, subcellular targeting and fine-tuning of phosphatase activity, largely explaining why PP2A is functionally involved in so many diverse physiological processes, sometimes in seemingly opposing ways. In this review, we highlight how PP2A holoenzyme biogenesis and enzymatic activity are controlled by a sophisticatedly coordinated network of five PP2A modulators, consisting of α4, PTPA, LCMT1, PME-1 and potentially TIPRL1, which serve to prevent promiscuous phosphatase activity until the holoenzyme is completely assembled. Likewise, these modulators may come into play when PP2A holoenzymes are disassembled following particular cellular stresses. Malfunctioning of these cellular control mechanisms contributes to human disease. The potential therapeutic benefits or pitfalls of interfering with these regulatory mechanisms will be briefly discussed.
ISSN: 1742-464X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Protein Phosphorylation and Proteomics
× corresponding author
# (joint) last author

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