Factor VII-activating protease promotes the proteolysis and inhibition of tissue factor pathway inhibitor
Kanse, Sandip M × Declerck, Paul Ruf, Wolfram Broze, George Etscheid, Michael #
Lippincott, Williams & Wilkins
Arteriosclerosis, Thrombosis and Vascular Biology vol:32 issue:2 pages:427-33
Factor VII-activating protease (FSAP) activates both factor VII and pro-urokinase and inhibits platelet-derived growth factor-BB, thus regulating hemostasis- and remodeling-associated processes in the vasculature. A genetic variant of FSAP (Marburg I polymorphism) results in low enzymatic activity and is associated with an enhanced risk of carotid stenosis and stroke. We postulate that there are additional substrates for FSAP that will help to explain its role in vascular biology and have searched for such a substrate.