Title: Parallel and antiparallel (G center dot GC)(2) triple helix fragments in a crystal structure
Authors: Vlieghe, D ×
Van Meervelt, Luc
Dautant, A
Gallois, B
Precigoux, G
Kennard, O #
Issue Date: Jan-1996
Publisher: Amer assoc advancement science
Series Title: Science vol:273 issue:5282 pages:1702-1705
Abstract: Nucleic acid triplexes are formed by sequence-specific interactions between single-stranded polynucleotides and the double helix. These triplexes are implicated in genetic recombination in vivo and have application to areas that include genome analysis and antigene therapy. Despite the importance of the triple helix, only limited high-resolution structural information is available. The x-ray crystal structure of the oligonucleotide d(GGCGAATTGG) is described; it was designed to contain the d(G . GC)(2) fragment and thus provide the basic repeat unit oi a DNA triple helix. Parameters derived from this crystal structure have made it possible to construct models of both parallel and antiparallel triple helices.
ISSN: 0036-8075
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Biochemistry, Molecular and Structural Biology Section
× corresponding author
# (joint) last author

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