Title: Synthesis of new acyclic nucleoside phosphonates (ANPs) substituted on the 1 ' and/or 2 ' positions
Authors: Kundarapu, Maheshwar ×
Marchand, Damien
Dumbre, Shrinivas G
Herdewijn, Piet #
Issue Date: Dec-2011
Publisher: Pergamon Press
Series Title: Tetrahedron Letters vol:52 issue:51 pages:6896-6898
Abstract: A series of 2' functionalized acyclic nucleoside phosphonate derivatives of 1-[3'-(phosphonomethoxy)propyl]uracil (1-4) have been synthesized together with the 1' and 2'-ethynyl derivatives of 9/1-[2'-(phosphonomethoxy)ethyl]adenine/thymine (5-7). Key intermediates leading to the latter series are (+/-)-[2-{diethyl(phosphonomethoxy)}-1-hydroxy]-but-3-yne (25) and (+/-)-diisopropyl{[2-hydroxy-4-(trimethylsilyl)but-3-yn-1-yl]oxy}methylphosphonate (30). Compounds 25 and 30 are easily obtained starting from (+/-)-solketal. (C) 2011 Elsevier Ltd. All rights reserved.
ISSN: 0040-4039
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Medicinal Chemistry (Rega Institute)
× corresponding author
# (joint) last author

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