Endocrine consequences of long-term intrathecal administration of opioids
Abs, R × Verhelst, J Maeyaert, J Van Buyten, JP Opsomer, F Adriaensen, Hugo Verlooy, J Van Havenbergh, T Smet, M Van Acker, K #
Journal of Clinical Endocrinology and Metabolism vol:85 issue:6 pages:2215-2222
Intrathecal administration of opioids is a very efficient tool in the long-term control of intractable nonmalignant pain. However, despite the well known role of opioids in endocrine regulation, few data are available about possible effects on hypothalamic-pituitary function during this treatment.