Title: Single-Step Antigen Loading and Activation of Dendritic Cells by mRNA Electroporation for the Purpose of Therapeutic Vaccination in Melanoma Patients
Authors: Bonehill, Aude ×
Van Nuffel, An M. T
Corthals, Jurgen
Tuyaerts, Sandra
Heirman, Carlo
Francois, Violaine
Colau, Didier
van der Bruggen, Pierre
Neyns, Bart
Thielemans, Kris #
Issue Date: May-2009
Publisher: Association for Cancer Research
Series Title: Clinical Cancer Research vol:15 issue:10 pages:3366-3375
Abstract: Purpose: A critical factor determining the effectiveness of currently used dendritic cell (DC)-based vaccines is the DC activation or maturation status. We have recently shown that the T-cell stimulatory capacity of DCs pulsed with tumor-antigen-derived peptides can be considerably increased by activating the DCs through electroporation with mRNA encoding CD40 ligand, CD70, and a constitutively active Toll-like receptor 4 (TriMix DCs). Here, we investigate whether TriMix DCs can be coelectroporated with whole tumor-antigen-encoding mRNA.
ISSN: 1078-0432
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Non-KU Leuven Association publications
× corresponding author
# (joint) last author

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