Title: Gliomas: Diffusion Kurtosis MR Imaging in Grading
Authors: Van Cauter, Sofie ×
Veraart, Jelle
Sijbers, Jan
Peeters, Ronald R
Himmelreich, Uwe
De Keyzer, Frederik
Van Gool, Stefaan
Van Calenbergh, Frank
De Vleeschouwer, Steven
Van Hecke, Wim
Sunaert, Stefan #
Issue Date: Mar-2012
Publisher: Radiological Society of North America
Series Title: Radiology vol:263 issue:2 pages:492-501
Abstract: Purpose:To assess the diagnostic accuracy of diffusion kurtosis magnetic resonance imaging parameters in grading gliomas.Materials and Methods:The institutional review board approved this prospective study, and informed consent was obtained from all patients. Diffusion parameters-mean diffusivity (MD), fractional anisotropy (FA), mean kurtosis, and radial and axial kurtosis-were compared in the solid parts of 17 high-grade gliomas and 11 low-grade gliomas (P < .05 significance level, Mann-Whitney-Wilcoxon test, Bonferroni correction). MD, FA, mean kurtosis, radial kurtosis, and axial kurtosis in solid tumors were also normalized to the corresponding values in contralateral normal-appearing white matter (NAWM) and the contralateral posterior limb of the internal capsule (PLIC) after age correction and were compared among tumor grades.Results:Mean, radial, and axial kurtosis were significantly higher in high-grade gliomas than in low-grade gliomas (P = .02, P = .015, and P = .01, respectively). FA and MD did not significantly differ between glioma grades. All values, except for axial kurtosis, that were normalized to the values in the contralateral NAWM were significantly different between high-grade and low-grade gliomas (mean kurtosis, P = .02; radial kurtosis, P = .03; FA, P = .025; and MD, P = .03). When values were normalized to those in the contralateral PLIC, none of the considered parameters showed significant differences between high-grade and low-grade gliomas. The highest sensitivity and specificity for discriminating between high-grade and low-grade gliomas were found for mean kurtosis (71% and 82%, respectively) and mean kurtosis normalized to the value in the contralateral NAWM (100% and 73%, respectively). Optimal thresholds for mean kurtosis and mean kurtosis normalized to the value in the contralateral NAWM for differentiating high-grade from low-grade gliomas were 0.52 and 0.51, respectively.Conclusion:There were significant differences in kurtosis parameters between high-grade and low-grade gliomas; hence, better separation was achieved with these parameters than with conventional diffusion imaging parameters.© RSNA, 2012.
ISSN: 0033-8419
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Translational MRI (+)
Research Group Experimental Neurosurgery and Neuroanatomy
Biomedical MRI
Clinical Residents Medicine
Laboratory of Pediatric Immunology
× corresponding author
# (joint) last author

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