Title: TRPV1 activation prevents nonalcoholic fatty liver through UCP2 upregulation in mice
Authors: Chen, Jing ×
Feng, Xiaoli
Zhao, Zhigang
Wang, Peijian
Sun, Jing
Yu, Hao
Yan, Zhencheng
Liu, Daoyan
Nilius, Bernd
Zhu, Zhiming #
Issue Date: Jul-2012
Publisher: Springer-Verlag
Series Title: Pflügers Archiv: European Journal of Physiology vol:463 issue:5 pages:727-732
Abstract: Nonalcoholic fatty liver is characterized by the fatty deformation and lipid deposition of hepatic parenchymal cells that are associated with cardiometabolic diseases. In this study, we report the effect of capsaicin on its receptor, transient receptor potential vanilloid 1 (TRPV1) cation channel, in preventing fatty liver formation. Functional TRPV1 has been detected in hepatocytes and liver tissues. TRPV1 activation by capsaicin reduced lipid accumulation and triglyceride level in the liver from wild-type (WT) mice. However, these effects were absent in the liver from TRPV1(-/-) mice. Chronic dietary capsaicin increased the hepatic uncoupling protein 2 (UCP2) expression in WT but not in TRPV1(-/-) mice (P < 0.01). We conclude that TRPV1 long-time activation might prevent high-fat diet-induced fatty liver in mice through upregulation of hepatic UCP2. Dietary capsaicin may represent a promising intervention in populations at high risk for fatty liver.
ISSN: 0031-6768
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Department of Cellular and Molecular Medicine - miscellaneous
× corresponding author
# (joint) last author

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